What best describes the relative location of Barcelona, Spain?

The relative location of Barcelona is best described by its proximity to other major cities in relation to cardinal directions and distances. The correct answer indicates that Barcelona is approximately 386 miles west of Madrid, which places it as a significant distance in a straight line and aligns with geographical knowledge. Additionally, saying that it is 644 miles south of Paris also contextualizes Barcelona's position in relation to another major European city.

This option accurately reflects the geographical relationship between Barcelona and both Madrid and Paris. The reference points of Madrid and Paris are particularly relevant because they highlight Barcelona’s position within Spain and Europe, demonstrating how far it lies from these hubs.

Other options misstate the distances or directional references relative to these cities, making the first choice the only one that accurately describes Barcelona's location within the context of European geography.